Year: 2013 | Month: June | Volume 2 | Issue 1
Gene expression profile in the small intestine of mice fed Lactobacillus acidophilus LAFTI L10
Abstract: <div>The effects of <i>Lactobacillus acidophilus </i>LAFTI L10 on gene expression in the</div><div>small intestine of mice was evaluated using microarrays. Male BALB/c mice were orally fed with 108 colony forming units of <i>L. acidophilus</i> in skimmed milk powder for 14 days. Control mice received skimmed milk powder without <i>L. acidophilus</i>. After 14 days, distal end of the small intestine was excised for microarray analysis of gene expression. <i>L. acidophilus</i>-fed mice altered the expression of genes such as CD40 ligand, CD200 receptor-3 and trefoil factor 2, which are involved in host defence mechanisms. Overall, the expression of functional genes influenced by<i> L. acidophilus</i> in the small intestine of mice offer as a basis for further investigation into its probiotic effects.</div>
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